SrasV1, Main, Exploration, bibRecord, 001D18

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

Identifieur interne : 001D18 ( Main/Exploration ); précédent : 001D17; suivant : 001D19

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

Auteurs : Sander Van Boheemen ; Miranda De Graaf ; Chris Lauber ; Theo M. Bestebroer ; V. Stalin Raj ; Ali Moh Zaki ; Albert D. M. E. Osterhaus ; Bart L. Haagmans ; Alexander E. Gorbalenya ; Eric J. Snijder ; Ron A. M. Fouchier

Source :

mBio [ 2150-7511 ] ; 2012.

RBID : PMC:3509437

Descripteurs français

KwdFr :
- ARN viral (génétique), Analyse de regroupements, Analyse de séquence d'ADN, Cadres ouverts de lecture, Coronavirus (), Coronavirus (génétique), Coronavirus (isolement et purification), Données de séquences moléculaires, Gènes viraux, Génome viral, Humains, Pays-Bas, Phylogénie, Pneumopathie virale (virologie), Régulation de l'expression des gènes viraux, Similitude de séquences d'acides aminés, Syndrome de détresse respiratoire de l'adulte (virologie).
MESH :
- génétique : ARN viral, Coronavirus.
- isolement et purification : Coronavirus.
- virologie : Pneumopathie virale, Syndrome de détresse respiratoire de l'adulte.
- Analyse de regroupements, Analyse de séquence d'ADN, Cadres ouverts de lecture, Coronavirus, Données de séquences moléculaires, Gènes viraux, Génome viral, Humains, Pays-Bas, Phylogénie, Régulation de l'expression des gènes viraux, Similitude de séquences d'acides aminés.
Wicri :
- geographic : Pays-Bas.

English descriptors

KwdEn :
- Cluster Analysis, Coronavirus (classification), Coronavirus (genetics), Coronavirus (isolation & purification), Gene Expression Regulation, Viral, Genes, Viral, Genome, Viral, Humans, Molecular Sequence Data, Netherlands, Open Reading Frames, Phylogeny, Pneumonia, Viral (virology), RNA, Viral (genetics), Respiratory Distress Syndrome, Adult (virology), Sequence Analysis, DNA, Sequence Homology, Amino Acid.
MESH :
- chemical , genetics : RNA, Viral.
- geographic : Netherlands.
- classification : Coronavirus.
- genetics : Coronavirus.
- isolation & purification : Coronavirus.
- virology : Pneumonia, Viral, Respiratory Distress Syndrome, Adult.
- Cluster Analysis, Gene Expression Regulation, Viral, Genes, Viral, Genome, Viral, Humans, Molecular Sequence Data, Open Reading Frames, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Amino Acid.

Abstract

ABSTRACT

A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the replicase gene of coronaviruses with completely sequenced genomes showed that HCoV-EMC/2012 is most closely related to Tylonycteris bat coronavirus HKU4 (BtCoV-HKU4) and Pipistrellus bat coronavirus HKU5 (BtCoV-HKU5), which prototype two species in lineage C of the genus Betacoronavirus. In accordance with the guidelines of the International Committee on Taxonomy of Viruses, and in view of the 75% and 77% amino acid sequence identity in 7 conserved replicase domains with BtCoV-HKU4 and BtCoV-HKU5, respectively, we propose that HCoV-EMC/2012 prototypes a novel species in the genus Betacoronavirus. HCoV-EMC/2012 may be most closely related to a coronavirus detected in Pipistrellus pipistrellus in The Netherlands, but because only a short sequence from the most conserved part of the RNA-dependent RNA polymerase-encoding region of the genome was reported for this bat virus, its genetic distance from HCoV-EMC remains uncertain. HCoV-EMC/2012 is the sixth coronavirus known to infect humans and the first human virus within betacoronavirus lineage C.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509437

DOI: 10.1128/mBio.00473-12
PubMed: 23170002
PubMed Central: 3509437

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the replicase gene of coronaviruses with completely sequenced genomes showed that HCoV-EMC/2012 is most closely related to <italic>Tylonycteris</italic>
 bat coronavirus HKU4 (BtCoV-HKU4) and <italic>Pipistrellus</italic>
 bat coronavirus HKU5 (BtCoV-HKU5), which prototype two species in lineage C of the genus <italic>Betacoronavirus</italic>
. In accordance with the guidelines of the International Committee on Taxonomy of Viruses, and in view of the 75% and 77% amino acid sequence identity in 7 conserved replicase domains with BtCoV-HKU4 and BtCoV-HKU5, respectively, we propose that HCoV-EMC/2012 prototypes a novel species in the genus <italic>Betacoronavirus</italic>
. HCoV-EMC/2012 may be most closely related to a coronavirus detected in <italic>Pipistrellus pipistrellus</italic>
 in The Netherlands, but because only a short sequence from the most conserved part of the RNA-dependent RNA polymerase-encoding region of the genome was reported for this bat virus, its genetic distance from HCoV-EMC remains uncertain. HCoV-EMC/2012 is the sixth coronavirus known to infect humans and the first human virus within betacoronavirus lineage C.</p>
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   |wiki=    Sante
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   |texte=   Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans
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Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans

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